|Commenced in January 1999 || Frequency: Monthly || Edition: International|| Paper Count: 10 |
Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering
3D Segmentation, Compression and Wireless Transmission of Volumetric Brain MR Images
The main objective of this paper is to provide an efficient tool for delineating brain tumors in three-dimensional magnetic resonance images and set up compression-transmit schemes to distribute result to the remote doctor. To achieve this goal, we use basically a level-sets approach to delineating brain tumors in threedimensional. Then introduce a new compression and transmission plan of 3D brain structures based for the meshes simplification, adapted for time to the specific needs of the telemedicine and to the capacities restricted by wireless network communication. We present here the main stages of our system, and preliminary results which are very encouraging for clinical practice.
Workplace Monitoring During Interventional Cardiology Procedures
Interventional cardiologists are at greater risk from
radiation exposure as a result of the procedures they undertake than
most other medical specialists. A study was performed to evaluate
operator dose during interventional cardiology procedures and to
establish methods of operator dose reduction with a radiation
protective device. Different procedure technique and use of
protective tools can explain big difference in the annual equivalent
dose received by the professionals. Strategies to prevent and
monitor radiation exposure, advanced protective shielding and
effective radiation monitoring methods should be applied.
Protein Delivery from Polymeric Nanoparticles
Aim of this work was to compare the efficacy of two
loading methods of proteins onto polymeric nanocarriers: adsorption
and encapsulation methods. Preliminary studies of protein loading
were done using Bovine Serum Albumin (BSA) as model protein.
Nanocarriers were prepared starting from polylactic co-glycolic acid
(PLGA) polymer; production methods used are two different variants
of emulsion evaporation method. Nanoparticles obtained were
analyzed in terms of dimensions by Dynamic Light Scattering and
Loading Efficiency of BSA by Bradford Assay. Loaded
nanoparticles were then submitted to in-vitro protein dissolution test
in order to study the effect of the delivery system on the release rate
of the protein.
Detection of Legionella pneumophila in Cooling Water Systems of Hospitals and Nursing Homes of Kerman City, Iran by Semi- Nested PCR
Legionella pneumophila is involved in more than 95%
cases of severe atypical pneumonia. Infection is mainly by
inhalation the indoor aerosols through the water-coolant systems.
Because some Legionella strains may be viable but not culturable,
therefore, Taq polymerase, DNA amplification and semi-nested-PCR
were carried out to detect Legionella-specific 16S-rDNA sequence.
For this purpose, 1.5 litter of water samples from 77 water-coolant
system were collected from four different hospitals, two nursing
homes and one student hostel in Kerman city of Iran, each in a brand
new plastic bottle during summer season of 2006 (from April to
August). The samples were filtered in the sterile condition through
the Millipore Membrane Filter. DNA was extracted from membrane
and used for PCR to detect Legionella spp. The PCR product was
then subjected to semi-nested PCR for detection of L. pneumophila.
Out of 77 water samples that were tested by PCR, 30 (39%) were
positive for most species of Legionella. However, L. pneumophila
was detected from 14 (18.2%) water samples by semi-nested PCR.
From the above results it can be concluded that water coolant
systems of different hospitals and nursing homes in Kerman city of
Iran are highly contaminated with L. pneumophila spp. and pose
serious concern. So, we recommend avoiding such type of coolant
system in the hospitals and nursing homes.
Study of Peptide Fragment of Alpha-Fetoprotein as a Radionuclide Vehicle
Alpfa-fetoprotein and its fragments may be an important vehicle for targeted delivery of radionuclides to the tumor. We investigated the effect of conditions on the labeling of biologically active synthetic peptide based on the (F-afp) with technetium-99m. The influence of the nature of the buffer solution, pH, concentration of reductant, concentration of the peptide and the reaction temperature on the yield of labeling was examined. As a result, the following optimal conditions for labeling of (F-afp) are found: pH 8.5 (phosphate and bicarbonate buffers) and pH from 1.7 to 7.0 (citrate buffer). The reaction proceeds with sufficient yield at room temperature for 30 min at the concentration of SnCl2 and (Fafp) (F-afp) is to be less than 10 mkg/ml and 25 mkg/ml, respectively. Investigations of the test drug accumulation in the tumor cells of human breast cancer were carried out. Results can be assumed that the in vivo study of the (F-afp) in experimental tumor lesions will show concentrations sufficient for imaging these lesions by SPECT.
Mutational Effect to Particular Interaction Energy of Cycloguanil Drug to Plasmodium Plasmodium Falciparum Dihydrofolate Reductase Enzymes
In order to find the particular interaction energy
between cylcloguanil and the amino acids surrounding the pocket of
wild type and quadruple mutant type PfDHFR enzymes, the MP2
method with basis set 6-31G(d,p) level of calculations was
performed. The obtained interaction energies found that Asp54 has
the strongest interaction energy to both wild type and mutant type of -
12.439 and -11.250 kcal/mol, respectively and three amino acids;
Asp54, Ile164 and Ile14 formed the H-bonding with cycloguanil
drug. Importantly, the mutation at Ser108Asn was the key important
of cycloguanil resistant with showing repulsive interaction energy.
Comparison of Different Neural Network Approaches for the Prediction of Kidney Dysfunction
This paper presents the prediction of kidney
dysfunction using different neural network (NN) approaches. Self
organization Maps (SOM), Probabilistic Neural Network (PNN) and
Multi Layer Perceptron Neural Network (MLPNN) trained with Back
Propagation Algorithm (BPA) are used in this study. Six hundred and
sixty three sets of analytical laboratory tests have been collected from
one of the private clinical laboratories in Baghdad. For each subject,
Serum urea and Serum creatinin levels have been analyzed and tested
by using clinical laboratory measurements. The collected urea and
cretinine levels are then used as inputs to the three NN models in
which the training process is done by different neural approaches.
SOM which is a class of unsupervised network whereas PNN and
BPNN are considered as class of supervised networks. These
networks are used as a classifier to predict whether kidney is normal
or it will have a dysfunction. The accuracy of prediction, sensitivity
and specificity were found for each type of the proposed networks
.We conclude that PNN gives faster and more accurate prediction of
kidney dysfunction and it works as promising tool for predicting of
routine kidney dysfunction from the clinical laboratory data.
Mathematical Model for Dengue Disease with Maternal Antibodies
Mathematical models can be used to describe the
dynamics of the spread of infectious disease between susceptibles
and infectious populations. Dengue fever is a re-emerging disease in
the tropical and subtropical regions of the world. Its incidence has
increased fourfold since 1970 and outbreaks are now reported quite
frequently from many parts of the world. In dengue endemic regions,
more cases of dengue infection in pregnancy and infancy are being
found due to the increasing incidence. It has been reported that
dengue infection was vertically transmitted to the infants. Primary
dengue infection is associated with mild to high fever, headache,
muscle pain and skin rash. Immune response includes IgM antibodies
produced by the 5th day of symptoms and persist for 30-60 days. IgG
antibodies appear on the 14th day and persist for life. Secondary
infections often result in high fever and in many cases with
hemorrhagic events and circulatory failure. In the present paper, a
mathematical model is proposed to simulate the succession of dengue
disease transmission in pregnancy and infancy. Stability analysis of
the equilibrium points is carried out and a simulation is given for the
different sets of parameter. Moreover, the bifurcation diagrams of our
model are discussed. The controlling of this disease in infant cases is
introduced in the term of the threshold condition.
Synchronization of 0.1 Hz Oscillations in Heart Rate and Blood Pressure: Application to Treatment of Myocardial Infarction Patients
Synchronization between 0.1 Hz oscillations in heart rate and blood pressure is studied and its change during vertical tilt is evaluated in 37 myocardial infarction patients. Two groups of patients are identified with decreased and increased, respectively, synchronization of the studied oscillations as a response to a tilt test. It is shown that assessment of synchronization of 0.1 Hz oscillations as a response to vertical tilt can be used as a guideline for selecting optimal dose of beta-blocker treatment in post-myocardial infarction patients.
Medical Image Segmentation Using Deformable Models and Local Fitting Binary
This paper presents a customized deformable model
for the segmentation of abdominal and thoracic aortic aneurysms in
CTA datasets. An important challenge in reliably detecting aortic
aneurysm is the need to overcome problems associated with intensity
inhomogeneities and image noise. Level sets are part of an important
class of methods that utilize partial differential equations (PDEs) and
have been extensively applied in image segmentation. A Gaussian
kernel function in the level set formulation, which extracts the local
intensity information, aids the suppression of noise in the extracted
regions of interest and then guides the motion of the evolving contour
for the detection of weak boundaries. The speed of curve evolution
has been significantly improved with a resulting decrease in
segmentation time compared with previous implementations of level
sets. The results indicate the method is more effective than other
approaches in coping with intensity inhomogeneities.