Excellence in Research and Innovation for Humanity

International Science Index

Commenced in January 1999 Frequency: Monthly Edition: International Paper Count: 4

Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering

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  • 4
    6981
    Colorectal Cancer Screening by a CEACAM-6 Immunosensor
    Abstract:
    The biomarker for colorectal cancer (CRC) is CEACAM-6 antigen (C6AG). Therefore, this study aims to develop a novel, simple and low-cost CEACAM-6 antigen immumosensor (C6AG-IMS), based on electrical impedance measurement, for precise determination of C6AG. A low-cost screen-printed graphite electrode was constructed and used as the sensor, with CEACAM-6 antibody (C6AB) immobilized on it. The procedures of sensor fabrication and antibody immobilization are simple and low-cost. Measurement of the electrical impedance at a definite frequency ranges (0.43 – 1.26 MHz) showed that the C6AG-IMS has an excellent linear (r2>0.9) response range (8.125 – 65 pg/mL), covering the normal physiological and pathological ranges of blood C6AG levels. Also, the C6AG-IMS has excellent reliability and validity, with the intraclass correlation coefficient being 0.97. In conclusion, a novel, simple, low-cost and reliable C6AG-IMS was designed and developed, being able to accurately determine blood C6AG levels in the range of pathological and normal physiological regions. The C6AG-IMS can provide a point-of-care and immediate screening results to the user at home.
    3
    14325
    A Strategy for Scaling-Up Vitamin A Supplementation in a Remote Rural Setting
    Abstract:
    Vitamin A deficiency is a public health problem in Zimbabwe. Addressing vitamin A deficiency has the potential of enhancing resistance to disease and reducing mortality especially in children less than 5 years. We implemented and adapted vitamin A outreach supplementation strategy within the National Immunization Days and Extended Programme of Immunization in a rural district in Zimbabwe. Despite usual operational challenges faced this approach enabled the district to increase delivery of supplementation coverage. This paper describes the outreach strategy that was implemented in the remote rural district. The strategy covered 63 outreach sites with 2 sites being covered per day and visited once per month for the whole year. Coverage reached 71% in an area of previous coverage rates of around less than 50%. We recommend further exploration of this strategy by others working in similar circumstances. This strategy can be a potential way for use by Scaling-Up-Nutrition member states.
    2
    15181
    The Active Imagination Technique for Bruxism Treatment
    Abstract:
    The research purpose was to evaluate the effect of Active Imagination Technique (AIT) for bruxism treatment. This project was approved by the Ethics Committee on Human Research (CAAE: 05619512.9.0000.0109). Twenty-one volunteers using interocclusal splint completed the study. Initially they filled in a questionnaire about their condition, composed of objective questions on signs and symptoms. Following they were underwent asingle session of AIT. After 15 days, the volunteers met again the same initial questionnaire. The results were compared and showed that the vast majority had pain symptoms, difficulty opening the mouth, pain when chewing, reduced, some of the participants abandoned the interocclusal splint during the evaluate period. It is concluded that the technique can be used in bruxism treatment. Results seem to be promising and demonstrates the need of highlighting Active Imagination Technique since it points a possibility of bruxism cure and that is unprecedented.
    1
    9996654
    Tuberculosis Modelling Using Bio-PEPA Approach
    Abstract:

    Modelling is a widely used tool to facilitate the evaluation of disease management. The interest of epidemiological models lies in their ability to explore hypothetical scenarios and provide decision makers with evidence to anticipate the consequences of disease incursion and impact of intervention strategies.

    All models are, by nature, simplification of more complex systems. Models that involve diseases can be classified into different categories depending on how they treat the variability, time, space, and structure of the population. Approaches may be different from simple deterministic mathematical models, to complex stochastic simulations spatially explicit.

    Thus, epidemiological modelling is now a necessity for epidemiological investigations, surveillance, testing hypotheses and generating follow-up activities necessary to perform complete and appropriate analysis.

    The state of the art presented in the following, allows us to position itself to the most appropriate approaches in the epidemiological study.